| UFC: Ultimate Fighting Championship | GBC |
| Ultima 3: Exodus | NES |
| Ultima 4: Quest of the Avatar | NES |
| Ultima 5: Warriors of Destiny | NES |
| Ultima 6: The False Prophet | SNES |
| Ultima 7: The Black Gate | SNES |
| Ultima Runes of Virtue | GB |
| Ultima: Runes of Virtue 2 | SNES |
| Ultimate Air Combat | NES |
| Ultimate Basketball | NES |
| Ultimate Fighter | SNES |
| Ultimate Muscle The Kinnikuman Legacy | GBA |
| Ultimate Paintball | GBC |
| Ultimate Qix | GEN |
| Ultraman | SNES |
| UN Squadron | SNES |
| Uncharted Waters | NES |
| Uncharted Waters | GEN |
| Uncharted Waters | SNES |
| Uncharted Waters: New Horizons | GEN |
| Uncharted Waters: New Horizons | SNES |
| Uninvited | NES |
| Uniracers | SNES |
| Universal Soldier | GEN |
| Unnecessary Roughness '95 | GEN |
| UNO | GBC |
| Untouchables | NES |
| Untouchables | SNES |
| Up 'n Down | COL |
| Urban Champion | NES |
| Urban Strike | GEN |
| Urban Strike | SNES |
| Utopia: The Creation of a Nation | SNES |
| Valis | GEN |
| Valis 3 | GEN |
| Vampire Master of Darkness | SGG |
| Van Helsing | GBA |
| Vanguard | 2600 |
| Vapor Trail | GEN |
| Vectorman | GEN |
| Vectorman 2 | GEN |
| Vegas Dream | NES |
| Vegas Stakes | SNES |
| Vegas Stakes | GB |
| Veggie Tales Larryboy and the Bad Apple | GBA |
| Venture | 2600 |
| Venture | COL |
| Vice Project Doom | NES |
| Victory | COL |
| Video Checkers | 2600 |
| Video Chess | 2600 |
| Video Olympics | 2600 |
| Video Pinball | 2600 |
| Videomation | NES |
| Viewpoint | GEN |
| Vigilante | SMS |
| Vigilante | PCE |
| Vigilante 8 | GBC |
| Vindicators | NES |
| Virtua Fighter 2 | GEN |
| Virtua Fighter Animation | SGG |
| Virtua Tennis | GBA |
| Virtual Kasparov | GBA |
| Virtual Pinball | GEN |
| Vortex | SNES |
| VR Troopers | GEN |
| VR Troopers | SGG |